TYROSINE IODINASE

Maturation of Receptor Tyrosine Kinases Tyrosine Phosphorylation Regulates

SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling.

Anaplastic large-cell lymphoma (ALCL) is frequently associated with the 2;5 translocation and expresses the NPM-ALK fusion protein, which possesses a constitutive tyrosine kinase activity. We analyzed SHP1 tyrosine phosphatase expression and activity in 3 ALK-positive ALCL cell lines (Karpas 299, Cost, and SU-DHL1) and in lymph node biopsies (n = 40). We found an inverse correlation between the...

Tyrosine Sulfation of Statherin

Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William et al. Arch Biochem Biophys 1997; 338: 90-96). In the present study we demonstrate the sulfation of a salivary secretory protein, statherin, by the tyrosylprotein sulfotransferase present in human s...

Tyrosine Phenol Lyase

Crystalline I,-tyrosine phenol lyase of Escherichia infermedia A-21 is inactive in the absence of added pyridoxal phosphate. Half-maximal enzymatic activity is obtained at a concentration of 1.3 x 10pB M pyridoxal phosphate. Binding of pyridoxal phosphate to the apoenzyme is accompanied by pronounced increase in absorbance at 340 and 430 rng. Holotyrosine phenol lyase requires K+ or NH4+ for it...

l-Tyrosine isopropyl ester

The title compound, C(12)H(17)NO(3), adopts a folded conformation with a C-C(NH(2))-C(=O)-O torsion angle of -95.9 (2)°. In the crystal, mol-ecules are linked by an O-H⋯N hydrogen bond, forming helical chains along the b-axis direction. Weak N-H⋯O and C-H⋯O hydrogen bonds are observed between the chains.